2025 Golden Globes — Best Performance by a Female Actor in a Motion Picture – Musical or Comedy

The Substance won Best Performance by a Female Actor in a Motion Picture – Musical or Comedy at the 2025 Golden Globes. All 6 nominees are listed below, winner first. The other nominees were Anora, Challengers, Emilia Pérez, Nightbitch and Wicked. Each film links to its complete award history. The links below go to the 2024 and 2026 Best Performance by a Female Actor in a Motion Picture – Musical or Comedy races.