A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Genres
Links
Awards Dominance
Wins
Nominations
1 Oscar · 1 Golden Globe · 1 Cannes
Won
2025
Makeup and Hairstyling
Pierre-Olivier Persin, Stéphanie Guillon and Marilyne Scarselli
Actress in a Leading Role
Demi Moore
Best Picture
Coralie Fargeat and Tim Bevan & Eric Fellner, Producers
Directing
Coralie Fargeat
Writing (Original Screenplay)
Written by Coralie Fargeat
2025
Best Performance by a Female Actor in a Motion Picture – Musical or Comedy
Demi Moore
Best Director - Motion Picture
Coralie Fargeat
Best Motion Picture - Musical or Comedy
The Substance
Best Performance by a Female Actor in a Supporting Role in any Motion Picture
Margaret Qualley
Best Screenplay - Motion Picture
Coralie Fargeat
2024
Best Screenplay
In Competition - Feature films
Coralie FARGEAT
Ranked by shared director, cast, genre, country & era
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